[visionlist] Re: CVNet - psychedelic effects on perception?
Larry Baitch
lbaitch at amvtlaser.com
Wed Apr 25 01:55:04 GMT 2007
It's not a MAJOR hallucinogen, but my empirical research at ARVO in
years 1982-1987 suggest the following papers by Tony Adams and Mert Flom
on marijuana:
Psychopharmacology (Berl). <javascript:AL_get(this, 'jour',
'Psychopharmacology (Berl).');> 1978 Jan 31;56(1):81-6. Related
Articles,
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=pubmed_Abstract&db=pubmed&cmd=Display&dopt=pubmed_pubmed&from_uid=415330>
Links <javascript:PopUpMenu2_Set(Menu415330);>
*Marijuana, alcohol, and combined drug effects on the time course of
glare recovery.*
*Adams AJ*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Adams+AJ%22%5BAuthor%5D>,
*Brown B*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Brown+B%22%5BAuthor%5D>,
*Haegerstrom-Portnoy G*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Haegerstrom%2DPortnoy+G%22%5BAuthor%5D>,
*Flom MC*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Flom+MC%22%5BAuthor%5D>,
*Jones RT*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jones+RT%22%5BAuthor%5D>.
The time course of light adaptation after intense light exposure is
significantly delayed by alcohol, marijuana, and a combined dose of
alcohol and marijuana. These effects were found in a double blind
experiment, using 10 subjects. The experimental treatments were
placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg of delta9
tetrahydrocannabinol (THC). and 0.75 ml/kg of 95% ethanol together
with 15 mg of THC. The marijuana-induced delay in recovery is
doserelated. Both drugs produce delayed recovery for at least 2 h
after drug ingestion. The combined alcohol and marijuana treatment
produces little more than the effect produced by either drug alone,
suggesting some antagonism between the drugs--a suggestion supported
by a significantly lower blood alcohol level for the alcohol dose
when combined with marijuana than when taken alone.
Publication Types:
* Clinical Trial <javascript:AL_get(this, 'ptyp', 'Clinical
Trial');>
* Controlled Clinical Trial <javascript:AL_get(this, 'ptyp',
'Controlled Clinical Trial');>
* Randomized Controlled Trial <javascript:AL_get(this, 'ptyp',
'Randomized Controlled Trial');>
* Research Support, U.S. Gov't, Non-P.H.S.
<javascript:AL_get(this, 'ptyp', 'Research Support, U.S.
Gov\'t, Non-P.H.S. ');>
PMID: 415330 [PubMed - indexed for MEDLINE]
------------------------------------------------------------------------
*2: *Am J Optom Physiol Opt. <javascript:AL_get(this, 'jour', 'Am J
Optom Physiol Opt.');> 1976 Dec;53(12):764-73. Related Articles,
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=pubmed_Abstract&db=pubmed&cmd=Display&dopt=pubmed_pubmed&from_uid=797262>
Links <javascript:PopUpMenu2_Set(Menu797262);>
*Alcohol and marijuana effects on ocular tracking.*
*Flom MC*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Flom+MC%22%5BAuthor%5D>,
*Brown B*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Brown+B%22%5BAuthor%5D>,
*Adams AJ*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Adams+AJ%22%5BAuthor%5D>,
*Jones RT*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jones+RT%22%5BAuthor%5D>.
Experienced alcohol and marijuana users were instructed to track
with their eyes a small spot that moved horizontally back and forth
in pendular (sinusoidal) motion across a 7.5-degree field. The
frequency of spot oscillation was gradually increased from 0.5 to
3.0 Hz in 40 sec. Eye movement recordings showed the frequency at
which smooth tracking and, soon thereafter, saccadic tracking broke
down. These smooth and saccadic cutoff frequencies were reduced
after administration of alcohol, but not after marijuana or placebo.
For low alcohol doses, smooth tracking was impaired and saccadic
tracking was unaffected, much like an effect previously reported for
barbiturates. Alcohol seems to affect smooth tracking by increasing
the central processing time required to generate the appropriate eye
movement. It affects saccadic tracking by slightly decreasing
saccadic velocity and to a greater extent by increasing latency
time, part of which may be devoted to central processing. The site
of action of alcohol appears to be central to both the paramedian
pontine reticular formation and the flocculus of the cerebellum.
Publication Types:
* Clinical Trial <javascript:AL_get(this, 'ptyp', 'Clinical
Trial');>
* Comparative Study <javascript:AL_get(this, 'ptyp',
'Comparative Study ');>
* Research Support, U.S. Gov't, Non-P.H.S.
<javascript:AL_get(this, 'ptyp', 'Research Support, U.S.
Gov\'t, Non-P.H.S. ');>
* Research Support, U.S. Gov't, P.H.S. <javascript:AL_get(this,
'ptyp', 'Research Support, U.S. Gov\'t, P.H.S. ');>
PMID: 797262 [PubMed - indexed for MEDLINE]
------------------------------------------------------------------------
*3: *Am J Optom Physiol Opt. <javascript:AL_get(this, 'jour', 'Am J
Optom Physiol Opt.');> 1975 Nov;52(11):729-35. Related Articles,
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=pubmed_Abstract&db=pubmed&cmd=Display&dopt=pubmed_pubmed&from_uid=1106208>
Links <javascript:PopUpMenu2_Set(Menu1106208);>
*Alcohol and marijuana effects on static visual acuity.*
*Adams AJ*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Adams+AJ%22%5BAuthor%5D>,
*Brown B*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Brown+B%22%5BAuthor%5D>,
*Flom MC*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Flom+MC%22%5BAuthor%5D>,
*Jones RT*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jones+RT%22%5BAuthor%5D>,
*Jampolsky A*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jampolsky+A%22%5BAuthor%5D>.
Static visual acuity was measured at two contrast levels (12 and
49%) in ten subjects in a double blind experiment involving five
drug conditions of alcohol and marijuana (0.5 ml and 1.0 ml/kg body
weight of 95% ethanol, 8 and 15 mg delta-9-tetrahydrocannabinol
(THC), and a placebo). We found no statistically significant change
in static visual acuity for any of the dose levels at any of the
measurement time up to six hours following drug ingestion; this is
sharply contrasted with the marked decrements in acuity which were
found in the same subjects under the same drug conditions when the
targets were in motion and required corrdinated eye movements for
their resolution.
Publication Types:
* Clinical Trial <javascript:AL_get(this, 'ptyp', 'Clinical
Trial');>
* Comparative Study <javascript:AL_get(this, 'ptyp',
'Comparative Study ');>
* Controlled Clinical Trial <javascript:AL_get(this, 'ptyp',
'Controlled Clinical Trial');>
* Research Support, U.S. Gov't, Non-P.H.S.
<javascript:AL_get(this, 'ptyp', 'Research Support, U.S.
Gov\'t, Non-P.H.S. ');>
* Research Support, U.S. Gov't, P.H.S. <javascript:AL_get(this,
'ptyp', 'Research Support, U.S. Gov\'t, P.H.S. ');>
PMID: 1106208 [PubMed - indexed for MEDLINE]
------------------------------------------------------------------------
*4: *Invest Ophthalmol. <javascript:AL_get(this, 'jour', 'Invest
Ophthalmol.');> 1975 Jan;14(1):52-5. Related Articles,
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=pubmed_Abstract&db=pubmed&cmd=Display&dopt=pubmed_pubmed&from_uid=1089090>
Links <javascript:PopUpMenu2_Set(Menu1089090);>
*Marijuana smoking and reduced pressure in human eyes: drug action
or epiphenomenon?*
*Flom MC*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Flom+MC%22%5BAuthor%5D>,
*Adams AJ*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Adams+AJ%22%5BAuthor%5D>,
*Jones RT*
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jones+RT%22%5BAuthor%5D>.
Normal pressure within the human eye was reduced after smoking a
socially relevant dose of marijuana (12 mg.
delta9-9-tetrahydrocannabinol), but only for light to moderate users
who experienced a substantial "high" and a state of peaceful
relaxation from the experimental dose. Analysis suggests an indirect
effect of the drug associated with relaxation-a psychophysiologic
state that can be produced by drug and nondrug means.
Publication Types:
* Clinical Trial <javascript:AL_get(this, 'ptyp', 'Clinical
Trial');>
* Controlled Clinical Trial <javascript:AL_get(this, 'ptyp',
'Controlled Clinical Trial');>
* Research Support, U.S. Gov't, Non-P.H.S.
<javascript:AL_get(this, 'ptyp', 'Research Support, U.S.
Gov\'t, Non-P.H.S. ');>
* Research Support, U.S. Gov't, P.H.S. <javascript:AL_get(this,
'ptyp', 'Research Support, U.S. Gov\'t, P.H.S. ');>
PMID: 1089090 [PubMed - indexed for MEDLINE]
********************************
Larry Baitch, OD, PhD, FAAO
President and
Director of Clinical & Technical Services
American Medical Vision Technologies
Phone: 734-347-8949
Toll Free: 888-838-2688
Fax: 734-213-6011
lbaitch at amvtlaser.com
www.amvtlaser.com
********************************
Sara C. Mednick, Ph.D. wrote:
> I would also recommend:
> Pihkal or Phenethylamines I Have Known And Loved: A Chemical Love Story.
> http://en.wikipedia.org/wiki/PiHKAL
>
> Quoting Mario Ferraro <ferraro at ph.unito.it>:
>
>> Aldous Huxley
>> The doors of perception
>>
>> It's quite old (1954) but it was considered a classic. ..
>> best regards
>> mario ferraro
>>
>> On Mon, 23 Apr 2007, Denis Pelli wrote:
>>
>>> The students in my undergraduate class in Perception have requested
>>> that I give them a lecture on effects of psychedelic drugs on
>>> perception. Can anyone recommend a good article or book?
>>>
>>> Denis Pelli
>>> Professor of Psychology and Neural Science
>>> NYU
>>> http://psych.nyu.edu/pelli/
>>>
>>> P.S.
>>> I've ordered these two books:
>>> Richard Evans Schultes, et al., Plants of the Gods: Their Sacred,
>>> Healing and Hallucinogenic Powers
>>> Timothy Leary's Psychedelic Reader
>>>
>>>
>>> -------------------------------------------------------------------
>>> To get information on using CVNet, send a note to:
>>> majordomo at mail.ewind.com
>>> In the body of the message, enter: info cvnet
>>>
>>>
>>
>> -------------------------------------------------------------------
>> To get information on using CVNet, send a note to:
>> majordomo at mail.ewind.com
>> In the body of the message, enter: info cvnet
>>
>>
>
>
>
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