[vslist] Postdoctoral Opportunity at Smith-Kettlewell, SF, CA
Russ Hamer
russ@ski.org
Mon, 11 Feb 2002 16:23:31 -0800
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Postdoctoral Opportunity in Computational & Experimental Analysis of
Retinal Processing
The Retinal Computational Modeling Laboratory at Smith-Kettlewell Eye
Research Institute (San Francisco, CA), headed by Russell D. Hamer,
Ph.D., is seeking a postdoctoral fellow to participate and receive
training in a research program aimed at elucidation of mechanisms
underlying normal and abnormal vertebrate rod and cone function.
Candidates with a background in single-cell electrophysiology and an
interest in quantitative modeling are encouraged to apply. The
start-date is flexible, but immediate applications are encouraged.
Please email a Curriculum Vita and a letter describing your interests
and experience to Russell D. Hamer (russ@ski.org).
For information about the training program at Smith-Kettlewell and the
application process, please see the relevant webpages at
http://www.ski.org/Welcome/Fellowships/fellowships.html. For more
information about Dr. Hamer’s lab see http://www.ski.org/RHamer_lab/.
Research Program. The approach of the lab is multidisciplinary,
combining computational modeling with electrophysiological recordings
from photoreceptors. An important strength of the program is the
commitment to development of a full-scale model of vertebrate
phototransduction in both rods and cones. By incorporating the best
current biochemical results, we are developing physiologically realistic
models of phototransduction to account for the critical features of
vertebrate rod and cone responses under both dark-adapted (DA) and
light-adapted (LA) conditions. Development of these models will advance
our understanding of the role photoreceptors play in shaping the overall
temporal properties and sensitivity at higher centers in the visual
system. In addition, the models can provide powerful tools for
evaluating new candidate mechanisms of phototransduction. They can be
used to simulate point mutations of genetic knockout manipulations and
allow one to test, noninvasively, putative mechanisms of retinal
diseases affecting photoreceptor function. Finally, models can be used
to identify specific receptoral immaturities in developing visual
systems.
Training at Smith-Kettlewell. The research environment at
Smith-Kettlewell is robust and promotes productive interactions between
labs. There is a high level of scientific cooperation at
Smith-Kettlewell, resulting in many joint publications. Therefore,
during the course of the training period, the trainee has the ongoing
opportunity for significant interaction with many researchers other than
the primary sponsor. For the trainee, these interactions provide easy
and comfortable access to the expertise afforded by a variety of
researchers and disciplines. Dr. Hamer’s lab also has an ongoing
collaboration with Juan I. Korenbrot at the University of California,
San Francisco (http://www.ucsf.edu/pibs/faculty/korenbrot.html).
--
Russell D. Hamer, Ph.D.
Scientist
Smith-Kettlewell Eye Research Institute
2318 Fillmore Street
San Francisco, CA 94115
russ@ski.org
415 345-2056 (office)
415 345-2159 (lab)
415 987-8228 (cellular)
415 345-8455 (fax)
925 287-8228(home)
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<html>
Postdoctoral Opportunity in Computational & Experimental Analysis of
Retinal Processing
<p>The Retinal Computational Modeling Laboratory at Smith-Kettlewell Eye
Research Institute (San Francisco, CA), headed by Russell D. Hamer, Ph.D.,
is seeking a postdoctoral fellow to participate and receive training in
a research program aimed at elucidation of mechanisms underlying normal
and abnormal vertebrate rod and cone function. Candidates with a background
in single-cell electrophysiology and an interest in quantitative modeling
are encouraged to apply. The start-date is flexible, but immediate
applications are encouraged. Please email a Curriculum Vita and a letter
describing your interests and experience to Russell D. Hamer (<a href="mailto:russ@ski.org">russ@ski.org</a>).
<p>For information about the training program at Smith-Kettlewell and the
application process, please see the relevant webpages at <a href="http://www.ski.org/Welcome/Fellowships/fellowships.html">http://www.ski.org/Welcome/Fellowships/fellowships.html</a>.
For more information about Dr. Hamer’s lab see <a href="http://www.ski.org/RHamer_lab/">http://www.ski.org/RHamer_lab/</a>.
<p>Research Program. The approach of the lab is multidisciplinary, combining
computational modeling with electrophysiological recordings from
photoreceptors. An important strength of the program is the commitment
to development of a full-scale model of vertebrate phototransduction in
both rods and cones. By incorporating the best current biochemical
results, we are developing physiologically realistic models of phototransduction
to account for the critical features of vertebrate rod and cone responses
under both dark-adapted (DA) and light-adapted (LA) conditions. Development
of these models will advance our understanding of the role photoreceptors
play in shaping the overall temporal properties and sensitivity at higher
centers in the visual system. In addition, the models can provide powerful
tools for evaluating new candidate mechanisms of phototransduction. They
can be used to simulate point mutations of genetic knockout manipulations
and allow one to test, noninvasively, putative mechanisms of retinal diseases
affecting photoreceptor function. Finally, models can be used to identify
specific receptoral immaturities in developing visual systems.
<p>Training at Smith-Kettlewell. The research environment at Smith-Kettlewell
is robust and promotes productive interactions between labs. There
is a high level of scientific cooperation at Smith-Kettlewell, resulting
in many joint publications. Therefore, during the course of the training
period, the trainee has the ongoing opportunity for significant interaction
with many researchers other than the primary sponsor. For the trainee,
these interactions provide easy and comfortable access to the expertise
afforded by a variety of researchers and disciplines. Dr. Hamer’s lab also
has an ongoing collaboration with Juan I. Korenbrot at the University of
California, San Francisco (<a href="http://www.ucsf.edu/pibs/faculty/korenbrot.html">http://www.ucsf.edu/pibs/faculty/korenbrot.html</a>).
<br>
<p>--
<br>Russell D. Hamer, Ph.D.
<br>Scientist
<br>Smith-Kettlewell Eye Research Institute
<br>2318 Fillmore Street
<br>San Francisco, CA 94115
<p>russ@ski.org
<br>415 345-2056 (office)
<br>415 345-2159 (lab)
<br>415 987-8228 (cellular)
<br>415 345-8455 (fax)
<br>925 287-8228(home)
<br> </html>
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